Police arrested five men after seizing a “large amount” of what is believed to be crack cocaine and heroin on Friday.
Members of the South Bedfordshire Tasking Team executed a drugs warrant at a property in Crawley Road, turning up a “large” haul in the search.
Substances will now be sent for forensic analysis.
The men, aged 51, 42, 38, 35, and 32 years, were arrested on suspicion of possession with intent to supply a class A drugs and are now being questioned by officers.
Speaking after the arrests, Detective Constable Craig Gurr, said: “This is a good result for Bedfordshire Police and shows what an important part the public play in cracking down on those people who supply illegal drugs in our town and I would like to thank them for their help.
“Today’s arrests make it abundantly clear that if you are involved in drugs in Luton you can expect to be arrested by us at any time – and in any place.
“I would continue to encourage members of the public who have information about illegal drug activities to contact the police. This information allows us to continue the fight against illegal drugs and the knock on problems this type of crime causes.
If you have any information relating to illegal drug activity in Luton you can contact Beds Police on 101 or Crimestoppers on 0800 555 111.