A section of the A505 Hitchin Road, Luton, will be closed for five nights from Monday, September 29, for essential road resurfacing work.
The works will be at the Butterfield Business Park roundabout and will be closed from 10pm till 5am.
Travelling from Luton, the A505 will be closed from its junction with Cannon Lane, Luton, as far as Lilley Bottom.
Travelling from Hitchin, the A505 will be closed from its junction with Pirton Road, Hitchin, as far as Cannon Lane, Luton.
Drivers should follow the diversions in place via the A6, A507 and the A600.
Work is scheduled to be completed by 5am on Saturday, October 4.