Hatters first team coach Hakan Hayrettin revealed his team had been battling a sickness bug in the week, before their 2-0 win over Oxford United on Saturday.
An early goal from Luke Wilkinson sent Luton on their way, before Jake Howells added a second after his penalty had been saved after the hour mark.
Hayrettin said: “It’s a great result for the football club and I think the boys showed great spirit and determination to see the game through.
“They’re a good team, we know what they’re going to bring to the table and I thought we were outstanding.
“We’ve had people with stomach upsets and the flu, mini epidemic at the club and we had to rethink the structure of the team today and it worked.
“The depth we’ve got in our squad is quite deep, we’ve got some good players coming back from injury and it worked for us.
“Ideally we would have had a lot more to players pick from, we didn’t, but the boys that played did terrific.”
“You know what our manager says, he doesn’t have a reserve team, he’s got a first team squad and that’s exactly what we’ve got.
“It’s a squad who are capable of playing on any given day and that epitomises what we’ve got, that drive, that determination, that never say die spirit against a very, very good team.
“Maybe their league position might be a bit false, but for us, we had to change a few things round and pick a team we thought would go and win the game.
“With players coming back from injury and illness, it was outstanding and we kept another clean sheet as well.”
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