The address in Harcourt Street was searched by police on Wednesday amid concerns it was being used for drug dealing.
During the raid, police found weapons including two large knives which were subsequently seized.
The team also found drugs, cash and drug paraphernalia.
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The property has been secured and a three-month partial closure order was granted at Luton Magistrates’ Court on Thursday.
One person was arrested at the address and has since been released under investigation.
Sergeant Simon Betts, from the Luton community team, said: “We are satisfied with the closure order granted by the court.
“We won’t tolerate drug related crimes, with the organised criminal networks involved in drugs supply driving much of the serious violence, exploitation and anti-social behaviour which blights our communities.
“We are working closely with our residents to identify locations used for drug dealing and other serious crime, and bring those responsible to justice.”
If you have concerns about suspicious behaviour, contact Bedfordshire Police online or by calling 101.
Information can also be reported to Crimestoppers anonymously on 0800 555 111.