Laxmanbhai Mulchandani, 64, from Harrow, was injured when his vehicle was involved in a serious collision on the southbound carriageway, near junction 12 (Flitwick) at around 4.30am.
He was taken to hospital, but succumbed to his injuries on Tuesday, February 26.
Sergeant Mark Atkins from the Bedfordshire, Cambridgeshire and Hertfordshire Roads Policing Unit, said: “Our thoughts are with Mr Mulchandani’s family at this time.
Man charged after £14.5k of cannabis seized at drug factory in Luton home
Picture shows aftermath of field fire in Sundon Park Road in Luton
Luton's Wigmore Park needs your vote in contest to find the nation's top green spaces
Youths spotted deliberately damaging fencing along the Luton to Dunstable busway
Plans to protect Luton parks being drawn up because council is 'ignoring' its own local plan says councillor
"If you have information, witnessed the collision, or have any dashcam footage to help us piece together the events leading up to this tragic incident, please do get in touch.”
Anyone with information about the incident is asked to call police on 101 or via the force's online reporting centre, quoting Operation Banksia.