Isuf Plaku, 38, of Tennyson Avenue, Luton, Eduart Plaku, 40, of Oxford Road, Luton, and Krenar Kopaci, of Southdrift Way, Luton were arrested and subsequently charged with conspiracy to supply Class A drugs.
More than 40 kilograms of what is believed to be Class A drugs, along with a significant amount of cash, was seized during the warrant.
The Eastern Region Special Operations Unit (ERSOU) tackles serious organised crime and the terrorism threat across the eastern region.
All three men have been remanded in custody.