The crash was reported on the A505 (Park Viaduct) at around 12.40pm and saw emergency services attend the scene en masse.
A Bedfordshire Police spokesman said: "We were called at around 12.40pm to reports of a collision between two vehicles in Park Street West, Luton.
"Police attended alongside the fire and ambulance services.
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"Two people have been taken to hospital and the road has now reopened."