Hatters at home to Shrimpers in Checkatrade Trophy
The Hatters finished top of their group stage with two wins and a defeat to ensure a home tie in the competition, while Southend came second in their group, with an identical record.
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Hide AdSpeaking before Town's opponents were known, boss Nathan Jones, who has already led his side to a 2-0 win over the Shrimpers in League One this season, was relieved to be at Kenilworth Road, saying: "That’s why it’s important to win the group, a home tie is important.
"As long as we’re at home, that’s fine by us as we’ve earned that with our first two victories."
Full draw, South B: Swansea U21s v Bristol Rovers; Oxford United v Tottenham U21s; Luton Tow v Southend United; Cheltenham Town v Newport County.
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Hide AdSouth Part A: Exeter City v Peterborough United; Cambridge United v Northampton Town; Portsmouth v Arsenal U21s; Chelsea U21s v AFC Wimbledon.
North Part B: Barnsley v Man City U21s; Port Vale v Stoke City U21s; Mansfield Town v Bury; Newcastle United v Macclesfield.
North Part A: Accrington Stanley v Lincoln City; Rochdale v Oldham Athletic; Sunderland v Notts County; Shrewsbury v Walsall.