Luton are playing in the Championship for the first time since the CHECK season
However, when was the last time that the Hatters came up against their 23 other opponents in a league match? The Luton News takes a closer look in reverse order below.
The Hatters' record-breaking 28 league game unbeaten run came to an end at the Valley last season. Town led through Harry Cornick's strike, before Lyle Taylor netted twice and Igor Vetokele scored, as Andrew Shinnie saw red late on.
The Hatters were held to a goalless draw by promotion rivals Barnsley in the last league game that former boss Nathan Jones took before leaving for Stoke City.
The Bees picked up the League Two champions trophy after seeing off Town 2-0 at Griffin Park. Karleigh Osborne scored on 73 minutes, as former Hatter Adam Newton then netted in stoppage time.
Jake Howells made his Luton debut as the Hatters were beaten 1-0 by Huddersfield in their final game of the 2007-08 season. Phil Jevons (right) goal with 13 minutes to go was enough for the visitors.
The Hatters returned pointless on their last trip to the City Ground as Nathan Tyson's 67th minute goal was enough for Forest to triumph.
Luton battled valiantly on their last visit to the New Den, as they held the Lions to a goalless draw.
The Hatters looked set for a draw in Wales with 20 minutes to go, before Sol Davis was dismissed. Town paid the price, Tom Butler netting the only goal nine minutes later.
Sam Parkin scored a last-gasp leveller as the Hatters drew 1-1 at Kenilworth Road on Leeds' last visit. Paul Huntington had put Leeds in front, until Parkin popped up at the death with an equaliser.
The Hatters lengthy wait for a win at the Rams continued as Lewin Nyatanga netted after 37 minutes to seal victory for the hosts who included former Town legend Steve Howard upfront.
Town looked to have done enough, leading 2-1 thanks to goals from Chris Coyne and David Bells penalty with nine to go. Dexter Blackstock levelled from the spot though and ex-Hatter Paul Furlong won it in the final minute
Former Hatter David Livermore put Hull in front, before Luton had to replace goalkeepers, Marlon Beresford off for Dean Brill. Michael Turner (62) made it 2-0, although Drew Talbot pulled one back with 20 to go.
A thrilling game saw Town come out on top. Behind to Deon Burton's strike, Bjorn Runstrom equalised, while a Tommy Spurr own goal put them in front. Glenn Whelan levelled, only for Drew Talbot to win it.
The infamous game in which Sol Davis saw red for Luton after his tackle on Mamady Sidibe. City had already been down to 10 men before then, Ricardo Fuller off, as the scores remained goalless.
Town were cruelly left with nothing at the Hawthorns. Falling behind to Jason Koumas's goal, they led 2-1, Keith Keane and Warren Feeney scoring, until conceding a late double to Kevin Phillips.
Luton and Cardiff played out a goalless draw at Kenilworth Road in their last meeting, with the hosts down to 10 men for the final 18 minutes, David Bell seeing red for his second yellow card.
Town were left to rue a last minute leveller in a 2-2 draw at St Andrews. Luton fell behind to ex-Hatter Gary McSheffrey's strike, as Rowan Vine (44) and Warren Feeney (77) made it 2-1, Neil Danns salvaging a point.
Two early goals were enough for the Hatters to emerge victorious at Kenilworth Road, as Rowan Vine netted on just two minutes and then Carlos Edwards added the second with 19 on the clock.
Ahmet Brkovic got Town on their way after 10 minutes, while Kevin Nicholls' penalty and Sol Davis made it 3-0 by the break. In the second period, Peter Holmes and Brkovic again completed the rout.
After losing 3-0 at the DW Stadium in the FA Cup three months earlier, the Hatters earned a point in their league visit as Stephen Howard (57) put them in front, only for Neil Roberts to equalise with 15 left.
Town hit back from conceding in the opening minute to Kevin Doyle to move 2-1 in front, Rowan Vine (2) and Dean Morgan netting. Doyle pulled one back in the final minute, but Luton held on.
Ten man Luton were well beaten at Kenilworth Road by the Cottagers. After Alan White was sent off on the half hour, Geoff Horsfield (2), Paul Trollope and Barry Hayles all fired home in an easy victory.
In their final game at Ayresome Park, Middlesbrougth secured the Division One title and promotion to the Premier League. John Taylor was on target for Luton, but John Hendrie's double won it for Boro.
Town kept up their impressive league form against Rovers at Kenilworth Road with a 2-0 win thanks to goals from Brian Stein and Steve White in front of 10,721 at Kenilworth Road.