The Terriers are without a win in six matches, and Nathan Jones will be viewing this game as an ideal opportunity to bag another three points and edge into the top half of a tightly-packed table.
Of course, the Hatters aren't on the best of runs themselves, and will be looking to end a run of three straight losses - albeit against some pretty strong opponents.
In recent times, Luton have had a decent run of results against their West Yorkshire opponents, winning two out of their last three matches. The last time the two sides met, back in November,
Meanwhile, it was an exciting deadline day for Hatters fans, as the club pulled off two transfer deals - swooping for both Elijah Adebayo and Tom Ince as Luton looked to add some more fire-power to their attacking unit.
With Kal Naithsmith also arriving earlier in the month, it was a successful window for Luton, who now have some added quality to see them through to the end of the 2020/21 campaign.
Here's all the latest news and transfer chat involving Luton Town and a number of their divisional rivals, as we start to gear up for another exhilarating weekend of second-tier football: