With the Africa Cup of Nations and the Asian Cup both starting this month, Premier League clubs will see a number of their players head to the Ivory Coast and Qatar for the tournaments.
The Luton News has taken a look at just who will be missing for the top flight sides in this gallery below.
1. AFC Bournemouth
AFCON: Dango Ouattara (Burkina Faso, pictured); Antoine Semenyo (Ghana). Photo: Stu Forster
2. Arsenal
AFCON: Mohamed Elneny (Egypt). ASIAN CUP: Takehiro Tomiyasu (Japan). Photo: Stuart MacFarlane
3. Aston Villa
Bertrand Traore (Burkina Faso). Photo: Nathan Stirk
4. Brentford
AFCON: Yoane Wissa (DR Congo, pictured); Saman Ghoddos (Iran); Frank Onyeka (Nigeria). ASIAN CUP: Ji-Soo Kim (South Korea). Photo: Ryan Pierse