Boro have twice proved a tough nut to crack on their two visits to Kenilworth Road this season.
Town secured a 2-0 victory over them in the league thanks to two goals from Alex Lawless in the last five minutes, but Nuneaton did even better in the FA Cup as they secured a replay with dogged performance to hold the Hatters to a goalless draw.
Wales U21 international Howells said: “We know it’s going to be a hard game. They’ve given us hard games every time they’ve come here, but hopefully if we’re good enough on the day we’ll be able to break them down and get a few goals.”
And he’s hoping that victory can help to reignite Town’s title challenge.
Howells added: “It’s good to get on a good run, everyone wants a good run in the FA Cup and obviously we want to kick back out form and get back to winning games so it’s a big game.”