Bedfordshire Police stated that 13 people have been injured, with one man’s condition described as critical.
Luton & Dunstable Hospital have issued a plea asking the public to avoid the accident & emergency department.
Emergency services remain heavily at the scene around Station Road and New Bedford Road, which is closed.
Fire crews from Luton and Stopsley are leading the rescue.
Commuters are being warned to avoid the area and expect long delays.